Background Axonal loss is a major determinant of disability in multiple sclerosis (MS). While acute inflammatory demyelination is a principal cause of axonal transection and subsequent axonal ...

THE demyelinating diseases of the nervous system remain a challenge to scientific investigation and a stumbling block in medical therapy. Comprising an important group of neurologic disorders, they ...

Axonal damage is the main pathological substrate of irreversible neurological disability in multiple sclerosis (MS). In MS, axonal damage can either be direct or secondary to demyelination, glial ...

The study, “ Microglia-mediated demyelination protects against CD8+ T cell-driven axon degeneration in mice carrying PLP defects,” was published in Nature Communications.

Surprisingly and in contrast to the prevailing view, they found an inverse relationship of axon loss and demyelination when comparing the disease models. Fibers that remained myelinated despite ...

Surprisingly and in contrast to the prevailing view, they found an inverse relationship of axon loss and demyelination when comparing the disease models.

Surprisingly and in contrast to the prevailing view, they found an inverse relationship of axon loss and demyelination when comparing the disease models.

Although this nonhuman primate model of optic nerve demyelination does not represent the autoimmune component of MS, or its correlated preclinical model EAE, it has the obvious advantage to target the ...