Removing EPO signaling in mouse liver tumors leads to tumor regression along with sensitivity to immunotherapy.

Erythropoietin-receptor signaling mainly acts via activation of STAT 5, but also crossactivates the antiapoptotic transcription factor NF-κB.

HONOLULU — Erythropoietin did not reduce the risk for death or severe disability among infants with hypoxic ischemic encephalopathy already being treated with hypothermia, according to the ...

We identified three independent intracellular signaling pathways involved in Epo-induced neuroprotection in vivo: Protein levels of phospho-Akt, phospho-MAPK 1 and 2, and Bcl-2 were increased ...

"Because both hypothermia and erythropoietin may initiate similar neuroprotective pathways during the acute phase of hypoxic-ischemic injury, including reduction of apoptotic, inflammatory, and ...

Erythropoietin, a treatment for newborns with critically low levels of oxygen or blood supply to the brain at birth, does not prevent death or disability, according to a new multinational study.

In patients with renal insufficiency associated with increased hemoglobin levels and polycythemia, the possibilities of recombinant erythropoietin overdosing and disorders such as neoplasms and ...

The importance of this EPO-moderated crosstalk between tumor cells and macrophages showed clearly when the researchers studied the combinatorial effect of simultaneously blocking the EPO signaling ...

The study focuses on a short, 10-amino-acid sequence called the "passport sequence," which facilitates the efficient trafficking of glycoproteins through the secretory pathway. When attached to ...

High erythropoietin levels in people over age 85 indicate a higher risk of death, according to a new study.

In contrast, diverse tumor cell lines have erythropoietin receptors, 20 and erythropoietin has effects on intracellular signaling pathways such as the Janus kinase–signal transducer activator of ...

When modified using a process known as epoxidation, two naturally occurring lipids are converted into potent agents that target multiple cannabinoid receptors in neurons, interrupting pathways ...