The direct transfer of primary amino and hydroxyl groups to arylmetals in a scalable and environmentally friendly fashion remains a formidable synthetic challenge. Here, it is demonstrated that ...

IntroductionMagnesium metal is dissolved in HCl in 500mL Florence flasks covered with balloons. The moles of each reagent are changed in each flask in order to demonstrate the limiting reagent concept ...

Solid-phase synthesis is the synthesis of chemical compounds whereby the reactant molecule is chemically bound to an insoluble material and reagents are added in the solution-phase. Excess ...

"Acetalization, a well-known reversible reaction between carbonyl compounds and alcohols, usually need excess of one of the reactant to compel reversible acetalization completion," Li said ...

Bio-catalysis offers a renewable, energy efficient, low waste, and affordable strategy for the synthesis of fine chemicals and commodities. The synthesis of many chemicals requires high temperatures, ...

Excess reagents as well as coupling and cleavage related by-products are solely removed by aqueous extractions. Therefore, intermediate isolation of the tag-bound peptide and excessive washing steps ...