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Oct. 26, 2022 — Researchers have identified a new signaling process involving G protein-coupled receptors (GPCRs), a cellular target already exploited by hundreds of diverse drugs.
This important study fills an gap in our knowledge of the evolution of GPCRs in holozoans, as well as the phylogeny of associated signaling pathway components such as G proteins, GRKs, and RIC8 ...
More information: Lijie Liu et al, Redox regulation of G protein oligomerization and signaling by the glutaredoxin WG1 controls grain size in rice, The EMBO Journal (2025). DOI: 10.1038/s44318-025 ...
Li C, Vides A, Kim D, Xue JY, Zhao Y, Lito P. The G protein signaling regulator RGS3 enhances the GTPase activity of KRAS. Science 2021;374:197-201. Crossref. PubMed. Web of Science.
More than a third of FDA-approved drugs work by targeting a G protein-coupled receptor, or GPCR. The human body has more than 800 types of GPCRs that provide cells with information about the ...