This important study fills an gap in our knowledge of the evolution of GPCRs in holozoans, as well as the phylogeny of associated signaling pathway components such as G proteins, GRKs, and RIC8 ...

Excessive signaling by G protein-coupled receptors (GPCRs) contributes to various human disorders, necessitating novel therapeutic strategies.

An engineered protein turns off the kind of immune cells most likely to damage tissue as part of type-1 diabetes, hepatitis, multiple sclerosis, shows a new study in mice.

As the days grow shorter, many animals prepare for the approaching winter by suspending reproduction. Insects, for example, accumulate energy stores while halting ovarian development through a process ...

SKNY-1 was previously shown to achieve up to 30% weight loss, reverse nicotine craving, and preserve muscle mass in an animal model-and is designed to avoid the CNS side effects that halted earlier CB ...

As the days grow shorter, many animals prepare for the approaching winter by suspending reproduction. Insects, for example, ...

Heterotrimeric G protein signaling likely modulates amebic motility and attachment to and killing of host cells, in part through activation of an RGS-RhoGEF (regulator of G protein signaling–Rho ...

Abstract G-protein-coupled receptors (GPCRs) remain major drug targets, despite an incomplete understanding of how they signal through 16 non-visual G-protein signal transducers (collectively named ...

Spirulina is a nutrient-dense cyanobacterium rich in proteins, phycobiliproteins, carotenoids, and polyphenols that deliver ...

Technology Networks spoke with Stefan Foser, vice president of global pharma at Bruker, to explore how they integrate ...