As neither Gsk3b nor β-catenin/TCF has been implicated in Frizzled/PCP signaling, we hypothesized that the observed activation of JNK and AP-1 reflected a novel, Gsk3b-independent activity of Frat.

The innate immune response is the body's first line of defense against infection, and a successful immune defense takes a village: a combination of physical barriers, chemical attacks, and an army of ...

Melanoma subpopulations that rapidly escape MAPK pathway inhibition incur DNA damage and rely on stress signalling (Nature Communications 2021) Published:6/3/2021 6/3/2021 • By Chen Yang , Chengzhe ...