A crucial molecule for brain health acts as a garbage collector of other fat molecules (lipids), despite also being a lipid ...

Glycerol-3-phosphate acyltransferases (GPAT) catalyze the first step in the synthesis of glycerolipids and glycerophospholipids. Microsomal GPAT, the major GPAT activity, is encoded by at least two ...

Kinetic parameters are reported for glycerol 3-phosphate dehydrogenase (GPDH)-catalyzed hydride transfer from the whole substrate glycerol 3-phosphate (G3P) or truncated substrate ethylene glycol (EtG ...

The PPP, a major glucose metabolic pathway that is upregulated in cancer cells, depends on TP activity to convert pentose into glycerol-3-phosphate (G-3-P), a glycolytic pathway intermediate that ...

Here, we reconstitute an enzymatic network for sustainable glycerol 3-phosphate synthesis inside large unilamellar vesicles. We exploit the Escherichia coli glycerol kinase GlpK to synthesize glycerol ...

Glycerol-3-Phosphate Acyltransferases 4 (GPAT4) is the key rate-limiting enzyme in the synthesis of triacylglycerols in the glycerophosphate pathway. Gene overexpression and gene knockout experiments ...

In this study, we report that mitochondrial glycerol 3‐phosphate dehydrogenase (mGPDH, also referred to as GPD2) is a critical regulator for skeletal muscle regeneration.

The recent discovery of a glucose detoxification enzyme provides novel therapeutics for obesity and diabetes, say scientists. This enzyme, named glycerol 3-phosphate phosphatase (G3PP), plays a ...

Abstract Sn-glycerol-3-phosphate dehydrogenase (GlpD) is an essential membrane enzyme, functioning at the central junction of respiration, glycolysis, and phospholipid biosynthesis. Its critical role ...