SEED Therapeutics Presentations at AACR 2025: AACR Poster 397 Title: Combinatorial Use of VHL- and KEAP1-based PROTACs Reveals Unexpected Synergy and Hook Effect Relief ...

The cancer antibody drug conjugates (ADCs) market is on the brink of significant expansion, with projections indicating a market opportunity exceeding US$ 50 Billion by 2030. This growth is fueled by ...

Tiny antibodies to fight the dangerous effects of opioids Date: October 9, 2024 Source: Université de Genève Summary: Opioid drugs are highly effective at relieving pain but come with severe ...

Leukemia inhibitory factor (LIF) is an IL-6 type cytokine involved in the inflammatory response, stem cell self-renewal and tumor progression, that binds to LIFR and gp130 on the cell surface. LIF is ...

Prozone Effect One major limitation is the "prozone effect" or "hook effect," where high levels of antibodies inhibit the binding of the reporter antibody, resulting in falsely low signals.

By attaching a chemotherapy drug to an antibody, doctors are able to deliver more potent cancer-fighting medicines directly into tumor cells, all while causing fewer side effects.

Effect of anti CTLA-4 and PD-1 monoclonal antibodies on systemic SDF-1 and galectin-3 levels through NLRP3 and MyD-88 pathways in preclinical models.

Toxins in the venom of black mambas (one shown) and certain other snakes can paralyze snakebite victims. A lab-made antibody that targets these toxins could be a step toward a universal antivenom ...