Insulin signaling in experimentally induced neonatal sepsis. Profound suppression of muscle protein synthesis and reduced activation of the insulin signaling proteins in skeletal muscle, such as ...

Now, a study published in Cell Communication and Signaling describes new molecular mechanisms to understand insulin resistance in skeletal muscle and to outline future drug targets for DM2.

Triacylglycerol. Skeletal muscle of obese and diabetic individuals is characterized by a greater size and number of lipid droplets. 13 Once assumed to be relatively inert, lipid droplets are now ...

(HealthDay)—Skeletal muscle TRIB3 mediates glucose-induced insulin resistance (GIIR) in a mouse model of diabetes, according to a study published online May 10 in Diabetes.

"In regards to insulin resistance and type 2 diabetes, having more AMPK activity in our skeletal muscle is probably a good thing because AMPK activation stimulates glucose uptake, increases fat ...

They fed five strains of mice either a normal or high-fat and high-sugar diet, and took samples of their skeletal muscle – the site of greatest insulin-triggered glucose uptake after eating.

New research reveals how exercise transforms muscles into communication hubs that release beneficial molecules throughout the ...

The skeletal muscles of men and women process glucose and fats in different ways. A study conducted by the University ...

Insulin not only lowers blood sugar levels, ... Hyperglycemia induces skeletal muscle atrophy via a WWP1/KLF15 axis. JCI Insight, 2019; 4 (4) DOI: 10.1172/jci.insight.124952; ...

A landmark study has shed new light on the molecular roots of insulin resistance, a hallmark of type 2 diabetes, by mapping protein-level changes in human skeletal muscle. The findings may pave the ...

Insulin-producing β-islet cells in the pancreas can be made aware of a lack of insulin in the blood in a mouse model of diabetes, through signals relayed by a soluble signaling molecule called T ...

Adrenomedullin disrupts insulin signaling in blood vessels, leading to systemic insulin resistance in obesity-associated type 2 diabetes, according to a new study by a team at the Max Planck ...