Tissues are made of cells and a protein support, termed extracellular matrix (ECM). ECM contains a variable proportion of a large variety of matrix and non-matrix proteins. The latter consists of ...

Sigvotatug Vedotin is an ADC that targets integrin αvβ6-positive tumor cells. It has an engineered antibody that ensures high ...

Dr. Hynes coined the term “integrin” for these wonderfully complicated molecules that “integrate” the extracellular matrix with the intracellular environment (the cytoskeleton, in particular).

This article describes the composition of the extracellular matrix and its essential roles in cell-cell adhesion, cell signaling and tissue repair.

Researchers elucidate the mechanics of cellular attachment For cells to assemble into tissues and whole organs, the extracellular matrix (ECM) as well as integrins are required.

Integrin binding to ECM is crucial for cell anchorage to the surrounding matrix, spreading, migration, and further activation of intracellular signaling pathways.

Cy-cles of integrin-mediated "gripping and let loose" allow cells to move in the protein meshwork of the extracellular matrix like a sailor climbs in the ship's rigging.

It exists in the extracellular matrix, or the molecular network surrounding cells and supports their signaling and structure.

Effect of extracellular matrix metalloproteinase inducer emmprin on ß1 integrin-mediated adhesion through a new partner, the kindlin-3, in human melanoma cells.

Adherent cells secrete, mold, reside in, and interact with a dynamic, proteinaceous milieu known as the extracellular matrix. Although it occupies the intercellular space and binds cells and tissues ...

Some of the major conserved molecular processes involve TGF-β, PDGF, CTGF, vasoactive compounds (endothelin-1 and angiotensin II), and integrin–extracellular matrix signaling pathways.