Relative to existing gene signatures, the STRESS signature better predicted not only whether cells would later develop into ...

Scientists create smart cells that administer automatic treatments from inside the human body, reacting within seconds to ...

Oncology, a team of expert scientists specializing in immuno-oncology extensively outlined the complexities involved in the ...

Learn more about the research of Mayo Clinic's Gene Editing and Cellular Engineering Laboratory led by David (Chun-Wei) D.

KIAA1199 regulates adipocyte differentiation via the osteopontin-integrin pathway, a complex mechanism involving AKT and ERK signaling pathways.

Integrin Signaling at a Crossroads Integrins serve as the cell's conduit to the outside world, sensing the external environment and passing on instructions: differentiate or not, adhere or move on, ...

Medically reviewed by Mary Choy, PharmD Biologics work by targeting proteins that cause inflammation in ulcerative colitis. As a result, certain biologics help decrease flare-ups and complications.

Conclusions: This research highlights the pivotal role of integrin signaling in mediating the invasive attributes of glioblastoma. The data underscore the importance of further exploring key ...

Researchers demonstrated the role of integrin signaling in vascular dysfunction associated with SARS-CoV-2 infection.

The upregulated integrin α1, α6A, and β4 can further activate the RAS/mitogen-activated protein kinase kinase (MEK)/extracellular signal-regulated kinase (ERK) pathway and promote β-catenin signaling ...

Integrin activation begins with the binding of a molecule called talin to the cytoplasmic tail. The resulting signal causes the integrin, which is then shifted to the ECS state, to bind to the ligand.