Although the heterotrimeric receptors for interleukin-2 (IL-2) and IL-15 have two subunits in common, these cytokines have contrasting roles in adaptive immune responses. Understanding the biology ...

Serum soluble interleukin-2 receptor level is more sensitive than angiotensin-converting enzyme or lysozyme for diagnosis of sarcoidosis and may be a marker of multiple organ involvement. The ...

Interleukin-2 (IL-2) inhibitors are immunosuppressive agents that block the activity of IL-2, a cytokine involved in the activation and proliferation ...

Research led by Naval Medical University's Changzheng Hospital in China reports that an off-the-shelf cell therapy built from ...

Interleukin-2 (IL-2) is a cytokine that is critical to the regulation of T-cell responses. IL-2 also has a huge range of immunostimulatory and immunomodulatory functions.

In 21 April Lancet Eric Tartour and colleagues from the Hôpital Européen Georges Pompidou, Paris, propose the use of soluble interleukin-2 receptor as a prognostic marker in head and neck cancer. The ...

HealthDay News — Soluble interleukin 2 receptor (sIL-2R) has slightly better diagnostic value than angiotensin-converting enzyme (ACE) for sarcoidosis in patients with uveitis, according to a ...

The increases in levels of interleukin-6, interferon-γ, CXCL9, and soluble interleukin-2 receptor coincided with the tumor lysis syndrome, peak chimeric antigen receptor T-cell infiltration, and ...

In the SILCAAT study, 1695 patients (849 receiving interleukin-2 plus antiretroviral therapy and 846 receiving antiretroviral therapy alone) who had a median CD4+ cell count of 202 cells per cubic ...

Yet that same stimulation is known to induce expression of the interleukin-2 receptor and production of the interleukin IL-2, which together should create a feedback loop of IL-2 signaling that is ...

Key takeaways: Rezpegaldesleukin is a first-in-class interleukin-2 receptor agonist that proliferates and activates regulatory T cells. The study reached its target enrollment of 396 patients.