For example, a 2015 case report involving a person with vitiligo showed the effectiveness of an oral JAK inhibitor called tofacitinib. The manufacturer of tofacitinib is also studying a topical ...

We think this is why some patients that don't do well on dupilumab, for example, do much better on a JAK inhibitor because it covers IL-4 and IL-13 in addition to some of the other cytokines that ...

Versus the second generation, for example, upadacitinib is one where, you know, they're more selective inhibitors of, for example, with upa it's a selective JAK1 inhibitor.

There's a lot of concerns, but, as well as evolving data on real world observational studies, for example, on the safety of JAK inhibitors continuing to evolve, so definitely a lot going on in ...

For example, JAK inhibitors should be used cautiously in patients ages 65 and older. Ideally, providers should encourage healthy lifestyle choices. If feasible, patients should be current on ...

Immune checkpoint inhibitors have changed the future of cancer care. These powerful treatments use the body’s own immune ...

For example, if you look at the original FREEDOM2, there was really no definition of JAK failure, so it's important to define it, which was subsequently done right when FREEDOM2 was reanalyzed. Oh ...

For example, adalimumab and etanercept can cause numbness and tingling; swelling on the face, feet, ... Janus kinase (JAK) inhibitors are targeted disease-modifying antirheumatic drugs (DMARDs).

The JAK inhibitor group had numerically more MACEs than did the adalimumab group, but the difference in risk was not statistically significant (54 vs 35 MACEs; weighted hazard ratio [HRw], 1.0; 95 ...

For example, in one small study of 30 patients with VEXAS, ... Singh A. Association between myeloid disorders and adult onset-inflammatory syndromes, successful treatment with JAK-inhibitors: ...