Quaid's leading role in Novocaine feels like a natural continuation of these genre-bent everymen. He plays Nathan Caine, a mild-mannered assistant bank manager who has congenital insensitivity to pain with anhidrosis (CIPA), a genetic disorder that impacts his nervous system to the point that he can't feel pain or temperature.

After starring in last month’s AI thriller “Companion,” Jack Quaid is back at the box office this weekend with “Novocaine,” an action comedy where he plays a man who can’t feel pain. The R-rated film from Paramount has made $1.

Actor Jack Quaid stars as a man who can't feel pain in "Novocaine," a new action film that opens in theaters Friday. Quaid, known for his role as Hughie in the hit series "The Boys," plays Nathan Cain,