Summary A study led by Weill Cornell Medicine reveals that the APOE3-R136S mutation delays Alzheimer’s disease by inhibiting the cGAS-STING immune pathway. This mutation suppresses inflammation in ...

This rare mutation is found in the APOE gene encoding a cholesterol transport protein (apolipoprotein E), and was first discovered by a laboratory in Christchurch, New Zealand. In 2019, scientists ...

4 Bange E, et al. KEAP1 and TP53 frame genomic, evolutionary, and immunologic subtypes of lung adenocarcinoma with different sensitivity to immunotherapy. Journal of Thorac Oncol. 2021;16:2065-2077.

KEAP1, the other protein in the pathway, acts as a sensor for reactive oxygen species and controls the availability of NRF2 for cell protection. "We've studied NRF2 and KEAP1 for a long time, because ...

Immunogenomic correlates and clinical outcomes with PCP chemo-immunotherapy in patients with STK11- and/or KEAP1-mutant advanced nsNSCLC. Credit: Nature (2024). DOI: 10.1038/s41586-024-07943-7 ...

The POSEIDON exploratory analysis that dovetailed into the TRITON investigation saw STK11 mutations in 14% of the patients with nonsquamous NSCLC (n = 87), KEAP1 mutations in 6% (n = 51), and KRAS ...

Overview of effect of DRP-104 on KEAP1 mutant tumors and T cells. Credit: Science Advances (2024). DOI: 10.1126/sciadv.adm9859 ...

The KEAP1/Nrf2 pathway is also found in TKI-resistant cells in lung cancer. Krall et al. (2017) investigated the inhibitory effects of EGFR, ALK (anaplastic lymphoma kinase), BRAF, and MEK in lung ...