Researchers Uncover Cause of Leptin Resistance – And How To Reverse It 90% of people with obesity have leptin resistance – new research has found a mechanism involved and a way to reverse it.

Most obese patients grow resistant to satiety signals from the hormone leptin. A new study shows that leptin sensitivity can be restored in mice, leading to weight loss.

The team found that rapamycin restores leptin sensitivity to diet-induced obese (DIO) mice, leading to significant loss of fat with only minimal effects on muscle.

Most obese patients grow resistant to satiety signals from the hormone leptin. A new study shows that leptin sensitivity can be restored in mice, leading to weight loss.

Defects in POMC-expressing neurons are also known to cause leptin resistance and obesity, Friedman notes, adding, "it was satisfying to find that an acquired form of leptin resistance targets this ...

But now Bowen Tan, Kristina Hedbacker, and other researchers in Friedman's Laboratory of Molecular Genetics have discovered a neural mechanism involved in leptin resistance-and, crucially, a way ...

Leptin resistance can lead to overeating and excess fat storage. Other health problems can mess with your leptin signaling too.

Leptin resistance is a major biological contribution to obesity, [utreglutide] presented clinically meaningful weight loss with metabolic improvement and with a favorable tolerability profile.

Mouse study published in Science Translational Medicine suggests an old approach to obesity, the leptin hormone, could improve efficacy of GLP-1 drugs.