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To further expand the knowledge concerning the NK inhibitory signal transduction via the NKG2A/CD94 receptor, we constructed the complete structure of the membrane-embedded NKG2A/CD94 receptor with ...

G-protein-coupled receptors (GPCRs) are the largest family of plasma membrane receptors, which can be activated by an external signal such as a ligand. Binding of GPCRs and ligands in the plasma ...

About 85 percent of New York City’s subway system still operates with this analog signal system. The outdated equipment is no longer manufactured and has to be manually operated, around the clock.

Here, we present a proteo-genomic cell-based CRISPR activation (CRISPRa) enrichment screening platform employing customized pooled cell surface receptor sgRNA libraries in combination with a magnetic ...

Signal transduction regulates the proper function of T cells in an immune response. Upon binding to its specific ligand associated with major histocompatibility complex (MHC) molecules on an antigen ...

Ligation of TNFRSF members by the corresponding TNFSF members induces signaling via dedicated signal transduction pathways (11, 14). At the same time, TNFSF ligation activates ligand-dependent signal ...

Signal transduction pathways are incredibly complex, diverse, and specific to the type of cell or tissue they target. Understanding them is the focus of several scientists and research projects ...

Cyclic nucleotide-modulated channels have important roles in visual signal transduction and pacemaking. Binding of cyclic nucleotides (cAMP/cGMP) elicits diverse functional responses in different ...

PIP2 is an important phosphoinositide that is present in around 1% of the plasma membrane. It is also involved in signal transduction of intracellular and extracellular components. There are two ...