Pneumonia is usually treated with antibiotics, but unfortunately these drugs are becoming less useful as bacteria develop resistance to them. Now, researchers at the National Institutes of Health ...

Scientists uncover how macrophages metabolize bacteria, influencing immune response, inflammation, and future therapies for antibiotic-resistant infections.

Findings reveal macrophages' role in immune modulation through bacterial metabolites, paving the way for improved therapies for infections and inflammation.

A macrophage with the mycobacterium M. avium. Bacteria like the one on the right are about to be broken down by lysosomes. But the blue strip in the middle contains bacteria that reside in ...

Macrophages salvage nutrients from the bacteria they phagocytose to regulate inflammatory responses, revealing immunometabolic targets to treat infections.

Zinc has been found to be important in keeping lung infections at bay in people with cystic fibrosis, whose immune cells' natural bacteria-fighting ability has been reduced by the genetic mutation ...

Immune cells that eat bacteria in the body don’t stash them in specialized compartments as once thought, but turn them into critical nutrients that build proteins, create energy and keep the cells ...

As antibiotic-resistant "superbugs" make infections trickier to treat, some in the medical community are turning to bacteriophages for backup. Also known as phages, these viruses exclusively target ...

Most dangerous bacteria are attacked by macrophages. The macrophage engulfs bacteria and immediately traps them in a separate cell compartment, or vesicle.

Macrophages destroy bacteria by engulfing them in intracellular compartments, which they then acidify to kill or neutralize the bacteria. However, some pathogenic bacteria, such as Salmonella ...

When alerted of an invasion, immune cells called macrophages surround and engulf bacteria, quarantining them inside a compartment called a phagosome.

This article reviews the mechanisms by which macrophages utilize soft metals to inactivate and destroy bacteria. Could this concept be key to the development of novel antimicrobial strategies?