When NSD2 was turned off, important markers like CD38 were reduced, and other genes normally silent in plasma cells were activated. The study indicated that NSD2 does not directly affect the main ...

How to find marker genes in cell clusters. ScienceDaily. Retrieved June 2, 2025 from www.sciencedaily.com / releases / 2022 / 07 / 220706092850.htm. Max-Planck-Gesellschaft.

In recent years, the analysis of single-cell and spatial data has revolutionized biomedical research, making it possible to observe what happens in biological samples with an unprecedented level of ...

Plasma cell leukemia is a rare and aggressive form of multiple myeloma. ... It has different genetic and molecular markers to secondary PCL. The average age at diagnosis is 61, ...

PURPOSEPrimary plasma cell leukemia (pPCL) is an aggressive subtype of multiple myeloma, which is distinguished from newly diagnosed multiple myeloma (NDMM) on the basis of the presence of ≥ 20% ...

They also discovered that the presence of CD59, a gene that had not previously been linked to IgG secretion, is a better predictor of high-producing plasma cells than other genetic markers already ...

Vaccine effectiveness relies on creating a strong antibody response that can be reactivated to fight future infections.

By integrating more than 200,000 single cell RNA-seq data, the team identified a common set of dysregulated genes in hPSC-derived insulin producing cell, including those in the mineral absorption ...

Terminal deoxynucleotidyl transferase (TdT)-negative T-cell lymphoblastic lymphoma with loss of the T-cell lineage-specific marker CD3 at relapse: a rare entity with an aggressive outcome.

Fig. 1. Most of plasma cells that arrive at bone marrow are short-lived B220(hi) MHC-II(hi) cells. A small fraction of them become immobilized to bone marrow niches and progressively differentiate ...