Cellular scaffolding secrets unlocked: scientists discover key to microtubule growth Scientists found out how naturally unstable filaments decide whether to grow or to shorten. 30 May 2025 Growing ...

imageimageMicrotubules in cells transiently interact with LRRK2 in a kinase-independent manner. While microtubule depolymerization impairs LRRK2-mediated Rab phosphorylation at membranes, stabilized ...

Southern Medical University scientists have reported the discovery and preclinical characterization of novel microtubule-inhibiting agents being developed for the treatment of cancer.

In quiescent yeast, a stable bundle of parallel microtubules is assembled from the centrosome by an original multistep mechanism that follows a precise temporality and involves Aurora B and various ...

Microtubule plus- and minus-ends are structurally distinct: plus-ends present a β-tubulin polymerization interface that contains the exchangeable nucleotide, whereas minus-ends present an α-tubulin ...

A multi-institutional research collaboration has revealed that the microtubule network, which plays a vital role in cell construction and polarization, utilizes the phase separation properties of ...

Heart disease remains the leading cause of morbidity and mortality worldwide. With the advancement of modern technology, the role(s) of microtubules in the pathogenesis of heart disease has become ...

By improving the efficiency of in vitro microtubule polymerization, a recent protocol can generate tubulin with controlled post-translational modifications from cell lines or brain tissues of ...

We allowed 24 clonal populations of yeast cells with beta‐tubulin mutations preventing proper microtubule polymerization, to evolve for ˜150 generations. At the end of the laboratory evolution ...

Using nocodazole, a synthetic tubulin-binding agent that disrupts microtubule polymerization, they showed that nocodazole-induced loss of microtubule polymerization disrupted basal body positioning ...