Dynamics of mitochondria in living cells: ... Wolter KG, Hsu YT, Smith CL, Nechushtan A, Xi XG and Youle RJ (1997) Movement of Bax from the cytosol to mitochondria during apoptosis. J.

Alterations in mitochondrial dynamics underlie various human diseases, ... Nunnari, J. Cell biology: mitochondrial dynamics and apoptosis -- the ER connection. Science 2012;337:1052-1054. Crossref ...

Dysregulation of mitochondrial dynamics has been linked to impaired development and cancer ... mitophagy, apoptosis, and cell division, while fusion supports ATP production and reactive ...

Their real world counterparts, the mitochondria, are increasingly seen as the main players in almost all of the important functions of a cell. ... fusion, and apoptosis.

Mitochondrial dynamics has recently come to the forefront as a therapeutic target in several diseases, including neurodegeneration, cancer, ... Ca2+ homeostasis and regulation of programmed cell death ...

Characterization of mitochondrial cell death pathways in C. elegansThe identification of CPS-6/EndoG, an apoptotic nuclease from mitochondriaMitochondrial endonuclease G is important for apoptosis in ...

Thus, they reflect Bax activity in mitochondria during apoptosis, demonstrating how apoptotic Bcl-2 proteins such as Bax remodel the supramolecular architecture of the MOM shell to further drive ...

Mitochondrial dynamics are pivotal in breast cancer metastasis, influencing metabolic flexibility, stemness, and therapy resistance. Targeting fission, fusion, and mitophagy offers a ...

Fragmentation and elongation of mitochondria lead to the activation of inflammatory processes in muscle cells, which result in the development of muscle atrophy, and a diminished resistance to ...

Now, collaborative research co-led by Dr. Julie St-Pierre's lab at the Faculty of Medicine sheds new light on the mysteries of mitochondrial dynamics and its likely role in the metastatic ...