CCHD pathogenesis and progression are associated with mitochondrial dysfunction through changes in metabolism, fission, and fusion.

A new study reveals that mitochondrial dysfunction plays a central role in the loss of Purkinje neurons in the cerebellum, contributing to motor impairments in people with multiple sclerosis (MS).

Evidence also suggests that defects in mitochondria directly contribute to symptoms of Parkinson’s disease, and could be both a cause and an effect of type 2 diabetes.

Chimera approach overcomes mitochondrial barrier to alter protein production in living cells by Universitätsmedizin Göttingen ...

Genetic mutations in many forms of ALS lead to early problems with the transport and function of mitochondria, a study found.

Further studies at the University of Tsukuba in Japan and elsewhere, using cells with varying levels of mitochondrial dysfunction caused by mtDNA mutations, showed that healthy mitochondria can ...

The researchers observed that the small molecule they’d identified, which they named WEHI-3773, inhibited BAX’s ability to break the cell’s mitochondria, preventing its death.

In fatty liver disease, for example, blocking access to pyruvate entry into mitochondria could encourage the body to use potentially dangerous fat that has been stored in liver cells.

BACKGROUND: Nearly half of adults have hypertension, a major risk factor for cardiovascular disease. Mitochondrial hyperacetylation is linked to hypertension, but the role of acetylation of specific ...

Aberrant mitochondrial function has been associated with an increasingly large number of human disease states. Observations from in vivo models where mitochondrial function is altered suggest that ...

BACKGROUND: Mitochondrial dysfunction is a key factor in the development of atherogenesis. METTL4 (methyltransferase-like protein 4) mediates N6- methyldeoxyadenosine (6mA) of mammalian mitochondrial ...