These genes code for proteins that control how often cells divide. However, when a tumor suppressor gene, such as BRCA2, undergoes a mutational change, the protein it codes for won’t function normally ...

This cutting-edge therapy works by genetically modifying a patient’s own T-cells, essentially reprogramming the immune system to recognize and attack cancer cells specifically.

They play a significant role in the metabolic reprogramming of cancer cells and TILs. However, precise mechanisms underlying mitochondrial dysfunction and its impact on the TME are poorly understood.

A new study shows how an anticancer drug triggers an “outside in” signal that gets it sucked into a cancer cell. The work, published Jan. 29 in Nature Communications, reveals a new signaling mechanism ...

"We have found a new mechanism by which tumor cells evade the immune system. In further studies, we will now examine IRGQ's influence on other types of cancer," emphasizes Đikić.

Once cells’ quality control mechanism is activated, IRGQ (red) accumulates in special cell organelles, the lsysosomes (green). This is also where the degradation of the non-functional MHC-I ...

First author Matthew Coelho, PhD, at the Wellcome Sanger Institute and Open Targets, said, “Cancer cells developing resistance to treatments is a huge problem, and having a rapid way to identify ...

Drosophila study discovers mechanism that could control longevity, cancer cell production by Lorena Anderson, University of California - Merced Editors' notes ...

Conventional cancer drugs work by triggering apoptosis, that is programmed cell death, in tumor cells. However, tumor cells have the ability to develop strategies to escape apoptosis, rendering ...

Researchers have, for the first time, observed a mechanism used by cancer cells to resist the effects of chemotherapy. The findings could be used to develop targeted drugs to help override it and ...

Cancer tumours eradicated by genetically modified immune cells T-cells that have been genetically edited to boost their anticancer activity have destroyed solid tumours in mice ...

Researchers from Karolinska Institutet have discovered a new molecular mechanism by which cancer cells safeguard themselves from oncogene-induced replication stress and propose a strategy to ...