Two lipoglycans, lipomannan (LM) and lipoarabinomannan (LAM), play various, albeit incompletely defined, roles in the interactions of mycobacteria with the host. Growing evidence points to the ...

While Mabs, like Mycobacterium chelonae, was known to display α- (1→3)-linked monomannoside substituents in place of the more widespread α- (1→2)-linked monomannoside substituents of the mannan domain ...

TMC207 exhibits a strong inhibitory effect against a large number of NTM, including Mycobacterium avium and Mycobacterium intracellulare, with MICs in the same range as those for M. tuberculosis ...

TMC207 is a first-in-class anti-TB diarylquinoline (also named R207910 or the 'J' compound) with activity against drug-sensitive and drug-resistant TB. TMC207 inhibits the proton pump of ...