Unfortunately, clinical Mycobacterium tuberculosis strains rapidly become resistant to bedaquiline, predominantly by overexpression of MmpL5. The proteins MmpL5 and MmpL4 are efflux transporters, ...

Chemists found a way to identify a complex sugar molecule in the cell walls of Mycobacterium tuberculosis, the world's deadliest pathogen. This labeling could lead to simpler, faster TB tests.

Genetic, ultrastructural, multi-omics, and biochemical tools reveal VirR as a central scaffold in Mycobacterium tuberculosis cell envelope remodelling, critical for extracellular vesicle production.

M. tuberculosis absorbs different kinds of sugars for different purposes. Lee wanted to zero in specifically on mannose-containing glycans, which the bacterium uses to build its cell wall.

Lipoarabinomannan (LAM) from the Mycobacterium tuberculosis cell envelope represents important targets for the development of new therapeutic agents against tuberculosis, which is a deadly disease ...

Called "Structure Based Discovery of Inhibitors of CYP125 and CYP142 from Mycobacterium tuberculosis," their work involves characterizing the enzymes using the UK's national synchrotron, Diamond ...

Mycolic acids are the key constituents of mycobacterial cell wall, which protect the bacteria from antibiotic susceptibility, helping to subvert and escape from the host immune system. Thus, the ...

M. Seidel et al., Identification of a novel arabinofuranosyltransferase AftB involved in a terminal step of cell wall arabinan biosynthesis in Corynebacterianeae, such as Corynebacterium glutamicum ...

TUBERCULOSIS: (TB) transmitted by Mycobacterium tuberculosis (Mtb) is one of the top 10 causes of death globally. Currently, the widespread occurrence of resistance toward Mtb strains is becoming a ...