Caspase-3 is a pivotal enzyme in the apoptosis pathway that is responsible for executing programmed cell death through the cleavage of key cellular proteins. Existing fluorescence-based probes for ...

As mentioned before, caspase‐3 can cleave GSDME, and there are conflicting reports of GSDME playing a role during secondary necrosis of apoptotic macrophages (Rogers et al, 2017; Lee et al, 2018).

A review of the scientific literature suggests the potential of caspase-4/5 as targets for a broad range of inflammatory diseases, including inflammatory bowel disease, hidradenitis suppurativa, and ...

Reviewer #3 (Public review): The manuscript "Regeneration following tissue necrosis is mediated by non-apoptotic caspase activity" by Klemm et al. is an exploration of what happens to a group of cells ...

Our lab previously established a method to study necrosis-induced regeneration in the Drosophila wing imaginal disc, which revealed a unique phenomenon whereby cells at a distance from the injury ...

Mechanistically, the cleavage of TDP-43 at Asp89 by HIV-1 relies on Vpu-mediated activation of Caspase 3, and pharmacological inhibition of Caspase 3 activity effectively suppressed the HIV-1-induced ...

Necroptosis As compared to necrosis, necroptosis is a caspase-independent process that occurs following the stimulation of tumor necrosis factor α (TNF-α).

Regulated necrosis is an emerging type of cell death independent of caspase. Recently, with increasing findings of regulated necrosis in the field of biochemistry and genetics, the underlying ...

Pro-apoptotic drugs could be used as host-directed therapies in TB to improve antimicrobial treatments and patient outcomes. Procedure: We evaluated [18F]-ICMT-11, a caspase-3/7-specific positron ...

Caspase-1 triggers programmed necrosis called pyroptosis by gasdermin-D (GSDMD) cleavage. GSDMD-deficient cells are, however, susceptible to caspase-1-mediated cell death. Researchers at Kanazawa ...

These findings suggest that SE-induced aberrant mitochondrial dynamics may be involved in translocation of active caspase-3 and HMGB1 into mitochondria, which regulate neuronal apoptosis and necrosis, ...