A research team led by Professor Takuya Yamamoto (Department of Life Science Frontiers) and Professor Yasuhiro Yamada at the University of Tokyo has developed a novel in vivo system that reveals how ...

Inhibiting the p38 MAPK-MK2 signaling pathway significantly boosts the efficacy of microtubule-targeting agents specifically in breast cancer cells, highlighting a potential new therapeutic strategy ...

Patients with spinal cord injury (SCI) may develop depression, which can affect their rehabilitation. However, the underlying mechanism of depression in SCI patients remains unclear. Previous studies ...

Pharmacological and RNAi approaches identified NF-κB as the major signaling pathway involved in suppressing AR expression by TNFα. In addition, p38α- and p38δ-MAPK were identified as suppressors of AR ...

There are three major subfamilies of mitogen-activated protein kinases (MAPK): the extracellular-signal-regulated kinases (ERK MAPK); the c-jun N-terminal kinase or stress-activated protein kinases ...

ERK, JNK, and P38 MAPK Signaling Pathways Mediate the Regulation of Notch4 Overexpression on A549 and H1299 Cells Proliferation, Apoptosis, and Migration The activity of MAPK family members including ...

This study aimed to investigate the high glucose damage on human retinal pigment epithelial (RPE) cells, the role of p38 MAPK signaling pathway and how dimethyl fumarate can regulate that. We carried ...

Introduction: Serine/Threonine Kinase 25 (STK25) is a stress response kinase related to sterile-20 (Ste20) kinase superfamily. STK25 plays roles in several biological processes and regulates glucose ...

Here, the authors delineate a novel pathway involving components of p38 MAP kinase signaling that participates in the control of glutamate receptor (GLR1) trafficking and GLR-1 mediated reversal ...