Proton pump inhibitors (PPIs) reduce or inhibit the production of stomach acid, which relieves symptoms of acid reflux and gastroesophageal reflux disease (GERD). These medications are available ...

α-Helix-mediated protein–protein interactions (PPIs) play a key role in the development of numerous infection and disease states. Modulating such interactions offers considerable therapeutic ...

Using this method, we identified 133 PPIs as putative targets for our inhibitory peptides (Supplementary Data Set 3). Second, we exploited the compiled knowledge of PPIs mediated by short peptide ...

Proton pump inhibitors (PPIs) are a class of very effective and generally safe medicines used to treat heartburn, gastroesophageal reflux disease (GERD), and gastric ulcers.But not everyone who ...

An independent, dose-response relationship was seen between proton pump inhibitor use and COVID-19 positivity, according to a study published in the American Journal of Gastroenterology. “We ...

Sehested TSG, Charlot M, Fosbøl EL, et al. Proton pump inhibitor use increases the associated risk of first-time ischemic stroke: a nationwide cohort study. Presented at: American Heart Association ...

Association of Proton Pump Inhibitors With Risk of Dementia. JAMA Neurology, 2016; DOI: 10.1001/jamaneurol.2015.4791; Lewis H. Kuller. Do Proton Pump Inhibitors Increase the Risk of Dementia?

More information: Andrew Brennan et al, An Intracellular Peptide Library Screening Platform Identifies Irreversible Covalent Transcription Factor Inhibitors, Advanced Science (2025). DOI: 10.1002 ...

Source Reference: Lassalle M, et al "Proton pump inhibitor use and risk of serious infections in young children" JAMA Pediatr 2023; DOI: 10.1001/jamapediatrics.2023.2900.

Proton pump inhibitors (PPIs), which are used to control acid reflux, are associated with an increased risk for migraine and other severe headache types, new research showed. Using data from the ...