This article highlights the current state of macromolecular gene delivery systems, their applications, and the ongoing ...

imageimageAAVPureMfg produces high-purity AAV vectors with reduced plasmid cost, which holds tremendous clinical and commercial significance. Inherent limitations in triple transfection are elucidated ...

Thus far, scientists have produced approved therapies using triple-plasmid transient transfection and adherent cells. But many envision a future where producer cell lines will take over for large ...

Herein, live confocal microscopy was used to track plasmid DNA during transfection of Chinese hamster ovary (CHO) and human embryonic kidney (HEK) cells to map key cellular processes central to ...

In this research, we achieved the cell transfection via applying electrical and mechanical stimulation to cells. A device called electrically induced microbubble generator was used to generate the ...

Second, either plasmid transfection or lentivirus transduction were used to deliver the CALM-SupRep gene therapy cargo. Regardless of the delivery mechanism of the CALM-SupRep payload, either by ...

This produces plasmid DNA in nuclease-free water, which can be used for a range of molecular biology methods, including transfection and cloning. Methods and results ...

The system streamlines maxi-scale plasmid purification and reduces the manpower and time needed to purify high-quality, transfection-grade plasmid. Since its introduction, AmMag Quatro has been used ...

Researchers deliver transfected nucleic acids as oligonucleotides or in a viral or plasmid vector, which carries the genetic material into the host cells. Transfection can be stable or transient.