A new study reveals how CRISPR gene editing could potentially eradicate Down syndrome.

Portsmouth’s chief of police shared an update on the city’s crime halfway through 2025. Overall crime remains down so far this year, but violent crime has increased.

The Portsmouth Humane Society takes in all kinds of smiling furry faces, but their newest guest comes off a little grumpy.

Pro Portsmouth unveiled the 48th Annual Market Square Day Festival & 10K Road Race logo that features a Portsmouth waterfront favorite: the tugboat.

Instagram auto-fills searches for “down syndrome” by suggesting “beautiful girl” and “down syndrome dance,” which implies users are on the hunt for such content.

Because life expectancy for individuals with Down syndrome has increased dramatically, investigators assessed the risk of age-related cardiovascular diseases in this population.

Social media accounts using AI to impersonate people with Down syndrome are spreading, CBS News analysis shows, garnering dollars and millions of views while exploiting real advocates.

Down syndrome itself is a genetic condition caused when an unusual cell division results in an extra full or partial copy of chromosome 21, according to the Mayo Clinic.

A home in Prentis Park burned down a year ago. Though the city says the property is still within the proper demotion timeline, neighbors want to know when that will happen.

The 2025 Pro Portsmouth Children's Day logo emphasizes love and kindness. Here's what to know about the event before you go May 4.

For his final capstone project, Snyder, a Rochester Native, directed a short film called Turn Table. The film spins a tale of a young man with Down syndrome who goes into a record store to find an ...