Cellular pathways can be controlled through proteolysis, which allows rapid responses to changes in the environment. However, proteolysis is irreversible, so it must be carefully regulated. Here ...

Mechanisms of intracellular proteolysis. The discovery of the lysosome (see, for example, Refs 3,4; see also Fig. 1 and Box 1) was a turning point in the studies on protein degradation.Several ...

For decades, the story of Alzheimer’s research has been dominated by a battle between amyloid-beta and tau amyloids, both of which can kill neurons and impact the brain’s abil ...

Proteolysis describes the breakdown of proteins into smaller units, such as polypeptides or amino acids. Image Credit: Juan Gaertner/Shutterstock.com It is a vital process in humans and animals ...

Panelists discuss recent phase 3 trials of novel endocrine agents in advanced breast cancer, highlighting benefits—especially ...

Proteolysis-targeting chimeras (PROTACs) are bifunctional molecules that leverage the body’s internal protein disposal system to target and degrade disease-causing proteins. Emerged in 2001 ...

Panelists discuss recent phase 3 trials introducing novel endocrine agents such as proteolysis-targeting chimeras (PROTACs) ...

Recent advances in the molecular design and applications of proteolysis targeting chimera-based multi-specific antiviral modality. Compuscript Ltd. DOI 10.15212/AMM-2023-0019. Keywords ...

More recently, effective proteolysis-targeting chimeras targeting EGFR-mutant cells have been developed using gefitinib or afatinib to bind the mutant EGFR receptor (protein of interest) and couple it ...

Why polyQ huntingtin resists proteolysis is unclear. However, caspase-3 activation initiated the cleavage of wildtype N-terminal huntingtin but not of mutant huntingtin, and the presence of mutant ...

ARV-766, a proteolysis targeting chimera (PROTAC) androgen receptor (AR) degrader, in metastatic castration-resistant prostate cancer (mCRPC): Initial results of a phase 1/2 study. Authors : Daniel P.