Sickle cell disease can lead to a severe complication known as acute chest syndrome (ACS), but the underlying mechanisms are not well understood.

The misshapen cells tend to block blood flow in the vessels, leading to frequent pain episodes, infections, and damage to organs.

Columnist Oluwatosin Adesoye, a doctor, sorts through the difference between sickle cell anemia and sickle cell disease — and more.

The more Betsy Adler learned about her family's medical history, the more interested and concerned she became. Several of her first cousins had been treated for cancer, and three of her male ...

Discover the current pipeline candidates advancing through the clinic for the treatment of sickle cell disease.

So far in 2025, the Trump administration has cut more than $1 billion in NIH grants. That includes a study on sickle cell ...

Raghu R. Chivukula, MD, Ph.D., a physician-investigator in the Departments of Medicine & Surgery and the Center for Genomic ...

This study identifies astrocyte-intrinsic mechanisms by which the LRRK2 G2019S, a mutation linked to familial Parkinson's disease, disrupts synaptic integrity in the anterior cingulate cortex. The ...

This case presents a woman in her late 50s with hidradenitis suppurativa (HS) who presented for weight loss, syncope and ...