Sickle cell disease can lead to a severe complication known as acute chest syndrome (ACS), but the underlying mechanisms are ...

Sickle cell disease can lead to a severe complication known as acute chest syndrome (ACS), but the underlying mechanisms are not well understood. A new study by Mass General Brigham investigators ...

DNA makes RNA, RNA makes protein, protein makes phenotype—was the guiding framework for understanding inheritance and disease ...

The misshapen cells tend to block blood flow in the vessels, leading to frequent pain episodes, infections, and damage to organs.

Columnist Oluwatosin Adesoye, a doctor, sorts through the difference between sickle cell anemia and sickle cell disease — and ...

Sickle cell trait evolved as protection against malaria, especially in tropical regions. Its discovery advanced understanding of genetic inheritance, but racial bias long hindered care for affected ...

The more Betsy Adler learned about her family's medical history, the more interested and concerned she became. Several of her first cousins had been treated for cancer, and three of her male ...

The first healthy volunteer has been dosed in a Phase 1 study of Cellarity's novel globin-switching therapy CLY-124 for ...

The core defect lies in mutations that compromise proteins such as ankyrin, spectrin, and band 3, which maintain the integrity of the red cell membrane.

Discover the current pipeline candidates advancing through the clinic for the treatment of sickle cell disease.

So far in 2025, the Trump administration has cut more than $1 billion in NIH grants. That includes a study on sickle cell ...