News

Researchers at Children's Hospital Los Angeles have discovered a key difference between the two main types of ...
Graphical Abstract Objective: Humans and mice with loss-of-function variants of genes in the TGF-β (transforming growth factor beta) signaling pathway develop aortic aneurysms. These aneurysms could ...
Oncology, a team of expert scientists specializing in immuno-oncology extensively outlined the complexities involved in the ...
New research has identified the gene Egr-1 as a critical regulator of immune balance, offering hope for autoimmune disease therapies.
Transforming growth factor-beta (TGF-β), a well-known morphogen, is recognized for its role in regulating growth and development.
For years, scientists have thought that TGF-Beta, a signaling protein that holds sway over an astonishing array of cellular processes from embryonic development to cancer, could only do its work once ...
MSK researchers have identified two signaling pathways that work together to spur the spread of lung cancer. Taking away one of those signals could help slow or stop metastasis, findings in animal ...
Why context is key for TGF-beta's role in cancer metastasis The study brings together two longstanding areas of research for the Massagué Lab: TGF-beta signaling and metastasis.
Objectives: Arteriovenous fistulae (AVF) are the optimal conduit for hemodialysis access in patients with end-stage chronic kidney disease (CKD); however, AVF have high rates of failure due to ...
This oscillatory role of TGF-β to fight against cancer or act as a traitor to collaborate and crosstalk with other tumorigenic signaling pathways and its betrayal within the cell depends upon the ...