New research has identified the gene Egr-1 as a critical regulator of immune balance, offering hope for autoimmune disease therapies.

The transforming growth factor β (TGF-β) signaling pathway exerts a dual role in oncogenesis, acting as a suppressor in healthy and early stage neoplastic tissues while promoting malignancy and ...

Transforming growth factor-beta (TGF-β), a well-known morphogen, is recognized for its role in regulating growth and development.

Loeys-Dietz Syndrome is a complex and multifaceted genetic disorder that requires a comprehensive and coordinated approach ...

MSK researchers have identified two signaling pathways that work together to spur the spread of lung cancer. Taking away one of those signals could help slow or stop metastasis, findings in animal ...

Background: Dysregulated BMP (bone morphogenetic protein) or TGF-β (transforming growth factor beta) signaling pathways are imperative in idiopathic and familial pulmonary arterial hypertension (PAH) ...

This oscillatory role of TGF-β to fight against cancer or act as a traitor to collaborate and crosstalk with other tumorigenic signaling pathways and its betrayal within the cell depends upon the ...

Transforming growth factor beta (TGF-β), a key molecule in the development of fibrosis, can regulate a series of biological processes, including the cell growth cycle, cell differentiation, immune ...

Graphical Abstract Objective: Humans and mice with loss-of-function variants of genes in the TGF-β (transforming growth factor beta) signaling pathway develop aortic aneurysms. These aneurysms could ...