To better conduct the analysis of nucleoside analogues, hydrophilic interaction liquid chromatography–tandem mass ...

KJ Muldoon, a 10-month-old baby, was diagnosed with the genetic disease carbamoyl-phosphate synthetase 1 deficiency after he was born. He got out of hospital on Tuesday.

The paper titled ‘Germline thymidylate synthase deficiency impacts nucleotide metabolism and causes dyskeratosis congenita’ was published in The American Journal of Human Genetics on Friday 5 August ...

Kinetoplastid and apicomplexan parasites include protozoans which are responsible for human diseases, and cause a serious impact on human health and the socioeconomic growth of developing ...

The thymidylate synthase provides thymidylate for DNA synthesis that leads to cell proliferation and is the most important target of 5-FU.

Inhibitors of thymidylate synthase are called suicide substrates because they irreversibly inhibit the enzyme. Molecules of this class include fluorouracil and 5-fluorodeoxyuridine.

The overexpression of thymidylate synthase has been associated with poor response in patients with rectal cancer treated with fluoropyrimidine for adjuvant therapy.

Polymorphisms in the thymidylate synthase gene (TYMS) had previously defined two risk groups associated with disparate tumor DS rates (60% v 22%). We conducted a prospective single-institution phase ...

Thymidylate Synthase But Not Excision Repair Cross-Complementation Group 1 Tumor Expression Predicts Outcome in Patients With Malignant Pleural Mesothelioma Treated With Pemetrexed-Based Chemotherapy ...

This study tried to find out if a substance called thymidylate synthase affected how people respond to chemotherapy for non small cell lung cancer (NSCLC).