How are individual transmembrane helices in polytopic membrane proteins delivered from the Sec translocon into the lipid bilayer? A new study on the aquaporin-4 water channel shows that they move ...

Seven-transmembrane (7TM) receptors form the largest superfamily of cell-surface receptors. They respond to a wide range of stimulants including light, hormones, neurotransmitters, and odorants.

Novel mode of assembly Interestingly, glycine and alanine sequences are more typically involved in the assembly of transmembrane helices (TMH), being small amino acids.