The peripheral endoplasmic reticulum (ER) forms a continuous, dynamic network of tubules that plays an important role in protein transport and quality control, cellular signaling, and stress response.

The Golgi body (or Golgi complex, apparatus), and Endoplasmic reticulum (ER) are both organelles found in the majority of eukaryotic cells. They are very closely associated and show both ...

Endoplasmic reticulum articles from across Nature Portfolio. ... Hwang et al. outline how tumour-induced ER stress responses alter the function of intratumoural immune cells and the efficacy of ...

A team of scientists has answered a long-standing question in cell biology, uncovering how the cell’s main energy currency, ATP, is transported into the endoplasmic reticulum (ER). Disrupted energy ...

DJ-1 is a protein with wide subcellular distribution and pleiotropic functions. The loss-of-function mutations of DJ-1 are associated with autosomal recessive early-onset Parkinson's disease yet the ...

The endoplasmic reticulum (ER) is the portion of the cell responsible for manufacturing and folding proteins. Proteins are essential for a wide range of cellular functions—as enzymes ...

Perturbations of endoplasmic reticulum function from many causes activate a signalling pathway referred to as the UPR 15, resulting in transcriptional activation of genes whose products promote ...

The endoplasmic reticulum is the protein-making factory within cells consisting of tightly stacked sheets of membrane studded with the molecules that make proteins. Now, researchers have refined a ...

The team is currently screening for small molecules that modulate SLC35B1 function, with the goal of developing targeted therapies to either enhance or inhibit ATP transport when needed. Reference: ...