Certain brain regions of healthy old mice and humans harbor monocyte-derived microglia. The transcriptome of some monocyte-derived microglia was identical to that of yolk sac-derived microglia.

Elephants seem to have 20 different copies of a tumor-suppressing gene known as p53. This gene encodes a protein, also known as p53, which serves as a crucial cell protector.

Pathos AI has secured $365 million in a series D raise as the artificial-intelligence-powered biotech looks to fund trials of solid tumor drugs sourced from Novo Nordisk and Prelude Therapeutics.

NTS071 is an oral small molecule allosteric reactivator targeting p53 Y220C with a novel scaffold. It selectively binds to the p53 Y220C mutant protein, improving its thermal stability, thereby ...

NAD de novo synthesis activity in the murine visceral yolk sac is essential for embryonic development and its perturbation due to genetic and maternal dietary factors causes NAD deficiency and ...

We found that the extra-embryonic visceral yolk sac endoderm exclusively synthesises NAD de novo during early organogenesis before the embryonic liver takes over this function. Under CNDD-inducing ...

The manifestation of a giant ovarian yolk sac tumor during late pregnancy is relatively rare. A yolk sac tumor is a highly malignant germ cell tumor that originates from primitive germ cells. It is ...

Researchers at Baylor College of Medicine have developed a new compound called d16 that can reduce tumor growth and overcome therapeutic resistance in mutant p53-bearing cancers in the lab. The ...

The p53 gene plays an important role in cell biology as it regulates the cell cycle and halts the formation of tumors. While the gene was discovered more than four decades ago, researchers are ...

Researchers assessed the impact of protein adduction on p53 tumor suppressor inhibition.

Researchers identified a novel mechanism by which expression of the tumor suppressor p53 paradoxically promotes liver cancer development in patients with chronic liver disease. By generating a ...