Learn more about the research of Mayo Clinic's Gene Editing and Cellular Engineering Laboratory led by David (Chun-Wei) D.

Vitamin C helps reactivate growth genes in your skin through DNA demethylation, promoting cell renewal, thickness, and a ...

Research from the University of Cincinnati reveals how the MYC oncogene alters PRPS enzymes, impacting redox homeostasis and ...

Colorectal cancer is the third most diagnosed type of cancer worldwide. Up to 80% of the cases are related to environmental ...

c-MYC controls global gene expression and regulates cell proliferation, cell differentiation, cell cycle, metabolism and apoptosis. According to some estimates, MYC is dysregulated in ≈70% of human ...

As a model, MYC gene was chosen for knockout using CRISPR-Cas9 method in HT29 and OVCAR8 cells. Students were involved in the design of MYC-specific gRNAs, subcloning into Cas9-carrying plasmid, and ...

C-Myc, a key member of Myc proton-oncogene family, is a pivotal factor for transcriptional regulation of genes that control acquisition and maintenance of stemness. Previous cancer research has ...

N-myc downstream regulated gene 1 (ndrg1) functions as a molecular switch for cellular adaptation to hypoxia eLife 11:e74031.

They observed overexpression of C-MYC in IPF mice’s lung tissue. Upregulation of C-MYC led to the activation of miR-9-5p which, in turn, negatively regulated the expression of TBPL1. These events ...

The MYC oncogene family plays an important role in neoplastic disease, and has been extensively studied over decades. Evidence showing the N-terminal and C-terminal regions of MYC can function as a ...

Myc is one of the most frequently mutated, widely studied, and overexpressed genes implicated in cancer.

We have shown that a c-Myc/miR17-92/PTEN axis regulates PI3K activity for positive selection of immature B cells (28). As PI3K signals are necessary to turn off RAG (17, 18, 20), we tested whether the ...