Learn more about the research of Mayo Clinic's Gene Editing and Cellular Engineering Laboratory led by David (Chun-Wei) D.

Vitamin C helps reactivate growth genes in your skin through DNA demethylation, promoting cell renewal, thickness, and a ...

As a model, MYC gene was chosen for knockout using CRISPR-Cas9 method in HT29 and OVCAR8 cells. Students were involved in the design of MYC-specific gRNAs, subcloning into Cas9-carrying plasmid, and ...

We confirmed that 4OH treatment induced recombination at both the c-myc and N-myc loci, effectively knocking out both Myc genes (Figures 3A,E,F). Live-imaging experiments using the IncuCyte system ...

Considering the important roles of c-Myc in driving the turnorigenesis of NPC, these results demonstrate that SLC35B4 drives HCC progression by stabilizing c-Myc through O-GlcNAcylation.

5MP1 is a novel oncogene that reprograms c-Myc translation in CRC. 5MP1 could be a potential therapeutic target to overcome therapeutic resistance conferred by tumor heterogeneity of CRC.

Synopsis c‐Myc heterodimerizes with Max to transcriptionally regulate target genes. This study shows that essential biological functions such as proliferation or differentiation can be initiated in ...

The transcription factor c-Myc amplifies the transcription of many growth-related genes in cancer cells, but its role as an oncogene is not fully understood.

PROVIDENCE, R.I. [Brown University] — A team of scientists based at Brown University has found that reducing expression of a fundamentally important gene called Myc significantly increased the healthy ...

In addition to its cytoplasmic role for translation, the seryl-tRNA synthetase also antagonizes the c-Myc transcription factor in the nucleus to transcriptionally repress the growth factor VEGFA and ...

The positive feedback regulation among c-MYC, NAMPT, DBC1, and SIRT1 described here provides an important insight into the function and regulation of the prototypic c- MYC oncogene. Our results ...

The wide-ranging biological roles of Myc oncogenes in normal and cancer cells has made c-Myc one of the most exhaustively studied genes, yet a unifying view on its functions has proven elusive 1 ...