We identify Ser83 on the RIα linker-hinge region as an AKAP11-dependent phospho-residue that modulates RIα-Cα binding to the autophagosome and cAMP-induced PKA activation. Decoupling AKAP11-PKA from ...

Specifically, the combined analysis of the cAMP-dependent changes in chemical shifts, 2° structure probabilities, hydrogen/hydrogen exchange (H/H) and hydrogen/deuterium exchange (H/D) protection ...

The key results indicate that protein synthesis is increased in response to dopamine and neuronal activity in the pyramidal neurons of the CA1 hippocampal area, mediated via the activation of ...

As PDE3B catalyzes the conversion of cAMP to AMP, it negatively regulates the cAMP-dependent PKA/CREB/CREBBP tumor suppressive pathway. Indeed, overexpression of PDE3B accelerated cell proliferation ...

Ohio’s Hospice Pathways of Hope Grief Counseling Center is offering support to grieving children and teens this summer at Camp Pathways.

A functionally independent pool of ciliary cAMP begs the question of whether specific cAMP signalosomes exist within the cilium, especially since the primary cilium and the cAMP pathway are involved ...

Synopsis This study reveals a cAMP signalosome in primary cilia that evokes a distinct gene expression program via PKA‐dependent CREB phosphorylation in the cilium. Chronic stimulation of this pathway ...

This pathway involves the sequential metabolism of extracellular cAMP to 5’-AMP and adenosine by ecto-phosphodiesterases (ecto-PDE) and ecto-5’-nucleotidases (CD73), respectively (86 – 88) (Figure 1).

Moreover, we showed that nuclear cAMP evokes the same YAP-dependent inhibition of the Hippo Pathway in a variety of cancers, suggesting tumor suppression by nuclear sAC is not limited to melanoma.

AKAP12 Signaling Complex: Impacts of Compartmentalizing cAMP‐Dependent Signaling Pathways in the Heart and Various Signaling Systems ...

Reprogramming of transcription factors by PRR-independent (cAMP) and PRR-dependent (curdlan) signaling induces new dendritic cell subset.

This study was performed to investigate the signaling pathway that mediates cyclic AMP (cAMP)-induced inhibition of histone deacetylase 8 (HDAC8) degradation, and the effect and underlying ...