New research offers clues into how APOE isoforms affect microglia function differently in Alzheimer's disease, leading to strikingly different risk profiles.

However, how these isoforms lead to strikingly different risk profiles is poorly understood. In this study, researchers looked at APOE in microglia, the brain's immune cells known to play a role ...

Pumilio differentially binds to RNA isoforms of the same gene, favoring long, neuronal 3′ UTRs. These longer 3′ UTRs tend to remain in the neuronal soma, whereas shorter UTR isoforms localize to the ...

Figure 2: Ribosome profiling of eIF2A-KO lines finds little impact of eIF2A on translation. (A) Ribosome profiling identifies a handful of mRNAs sensitive to eIF2A depletion. Scatter plot of log2 ...

Importance of growth hormone molecular heterogeneity as a partial mechanism for somatogenic adaptations to physical activity Growth hormone (GH) exhibits a great deal of molecular heterogeneity (there ...

Methods: GCN2 inhibition by AP030 was determined using a biochemical Lanthascreen assay and a cell based HTRF assay measuring eIF2a phosphorylation following stimulation with Borrelidin. Kinase ...

Increased demands for pDNA for emerging nucleic acid-based vaccines and therapies exacerbate the need to remove bottlenecks from production.

Using ribosome profiling, RNA-Seq and reporter based assays authors evaluated the role of eIF2A protein under regular or stress conditions (cells starved for branched amino acids). Authors found that ...

To examine if the isoforms have similar or distinct roles in the two main RMS subtypes, we examined the expression and function of BRD4 isoforms in ARMS.

Co-aggregation involving different amyloidogenic sequences has been emphasized recently in the modified amyloid cascade hypothesis. Yet, molecular-level interactions between two predominant β-amyloid ...

On April 24, 2023, a new research paper was published in Oncotarget, entitled, “Differential silencing of STAT3 isoforms leads to changes in STAT3 activation.” ...