Proteins are among the most studied molecules in biology, yet new research shows they can still hold surprising secrets. Researchers have discovered previously undetected chemical bonds within ...

David Liu and Richard Merkin of the Broad Institute of MIT and Harvard, along with Columbia professor Sam Sternberg, have ...

The Stowers Institute for Medical Research announces the addition of two new scientists whose research investigates the ...

This valuable study focuses on defining how the HSP70 chaperone system utilizes J-domain proteins to regulate the heat shock response-associated transcription factor HSF1. Using a combination of ...

At MIT, one genome researcher is testing a different approach. Bin Zhang, associate professor of chemistry and the leader of ...

This approach provides a versatile framework for the semisynthesis of neurotrophins and related proteins that also require long chaperone peptides for proper folding. This study presents the first ...

This is just the first step but our work shows it is possible to decipher the language of protein aggregation. This is incredibly important for our understanding of human disease but also to guide ...

This is just the first step, but our work shows it is possible to decipher the language of protein aggregation. This is incredibly important for our understanding of human disease, but also to ...

Scientists using living human brain tissue have shown for the first time how a toxic form of a protein linked to Alzheimer's can stick to and damage the connections between brain cells. Small ...

By studying a minimal synthetic version of the full-length human tau, scientists can better ... plays a crucial role in protein folding and aggregation. The P301L mutation appears to directly ...