ATR activates mTORC1 by increasing phosphorylation and expression of the de novo cholesterol synthesis enzyme lanosterol synthase in cancer cells. While ATM activates mTORC1 via TSC1/2, ATR’s ...

Another strategy involves using existing drugs that inhibit mTORC1, a pathway already targeted in other cancers, which could be repurposed for liver cancer patients with increased VPS72 activity.

Synopsis Extracellular acidity is a common immunosuppressive feature of tumors. This study reveals that low pH suppresses T-cell functions and alters IL-2/IL-2R, mTORC1, and c-Myc signaling, as well ...

Importantly, the mTORC1 (mTOR complex 1) pharmacological inhibitor rapamycin suppressed EPC proliferation and ameliorated CCM pathogenesis in Pdcd10BECKO mice. Mechanistic studies suggested that ...

This work is published in Nature Aging in the paper, “ A mild increase in nutrient signaling to mTORC1 in mice leads to parenchymal damage, myeloid inflammation, and shortened lifespan.

Abstract Gene variants that hyperactivate PI3K-mTOR signaling in the brain lead to epilepsy and cortical malformations in humans. Some gene variants associated with these pathologies only ...

The growth and proliferation of endothelial cells is promoted by a protein known as mTORC1. Controlling its activity is important to organise a coherent branching of blood vessels and alterations ...

Although the role of growth factor signaling upstream of mTORC1 in aging has been investigated extensively, the involvement of signaling components participating in the nutrient sensing branch is less ...

Figure 2. Feedback regulation of mTORC2 activity. Several downstream signals of mTORC2, such as FBW8-IRS, mTORC1-GRB10-IRS, mTORC1-S6K-IRS, Akt, and FoxO, function as negative or positive regulators ...

ATF4 is a metabolic effector of mTORC1 signaling, co-opted to induce gene targets involved in amino acid synthesis, uptake, and tRNA charging, contributing to mTORC1-driven protein and glutathione ...