In a new discovery, chronic pain has been shown to be physiologically different from acute pain and now scientists have the roadmap for how to target it.

Our study demonstrated that sialylation regulates melanogenesis through the activation of ERK and the suppression of PKA/CREB signaling pathways. These pathways are involved in the regulation of ...

Abstract Protein Kinase A (PKA) is regulated spatially and temporally via scaffolding of its catalytic (Cα) and regulatory (RI/RII) subunits by the A-kinase-anchoring proteins (AKAP). By binding to an ...

Stress hormones activate the β-adrenergic receptor/PKA pathway, while obesity-related signals mainly use the PKD pathway. This suggests that both stress and obesity can fuel pancreatic cancer ...

This figure illustrates a putative relationship between adipose CX3CL1 and brain BDNF, and its age-related changes. In young mice, steroid hormones contribute to maintaining brain BDNF levels via ...

Two alternative models of PKA activation were tested in neurons, and the results support the classical model in which the catalytic subunit dissociated from the regulatory subunit upon activation.

Bear bile powder inhibits the release of NLRP3 by activating the cAMP/PKA/CREB signaling pathway to treat dextran sulfate sodium-induced colitis in mice Xia & He Publishing Inc.

Ca 2+ and PKA interact closely (Grewal et al, 2000; Ni et al, 2011); for instance, through calcium-mediated phosphorylation of CREB through the PKA-RAP1-ERK pathway.

Our study indicates that the interactions between CX3CR1 and CX3CL1 are crucial in the maturation of CCM lesions and propensity to CCM immunothrombosis. In particular, this pathway regulates the ...

New research by scientists at University of California San Diego has shown that cells regulate cAMP/PKA signaling by forming liquid droplets that segregate excess PKA catalytic subunits where they can ...

It's called the cAMP/PKA signaling pathway for its two main actors -- cAMP (cyclic adenosine monophosphate) and PKA (cAMP-dependent protein kinase).

Corrigendum: Dopamine homeostasis imbalance and dopamine receptors-mediated AC/cAMP/PKA pathway activation are involved in aconitine-induced neurological impairment in zebrafish and SH-SY5Y cells ...