LC3 and Autophagy - PubMed
Microtubule-associated protein 1A/1B-light chain 3 (LC3) is a soluble protein with a molecular mass of approximately 17 kDa that is distributed ubiquitously in mammalian tissues and …
LC3B is an RNA-binding protein to trigger rapid mRNA ... - Nature
Mar 17, 2022 · In this study, we demonstrate that LC3B, a central protein in autophagy, is an RBP with a binding preference for the AAUAAA consensus motif. Direct binding of LC3B to mRNAs …
MAP1LC3B - Wikipedia
LC3 also functions—together with autophagy receptors (e.g. SQSTM1)--in the selective capture of cargo for autophagic degradation. [15] Independent of autophagosomes, a single soluble LC3 …
The role of LC3B in autophagy as an RNA-binding protein - PMC
Our recent study revealed that LC3B binds to RNAs with a preference for the consensus AAUAAA motif and recruits the CCR4-NOT deadenylase complex. Consequently, LC3B elicits rapid …
LC3B: A microtubule-associated protein influences disease …
Feb 1, 2025 · LC3B drives autophagy via interaction with autophagy-related proteins, autophagosome-lysosome fusion, and transcriptional cofactor activity. LC3B modulates …
Beyond autophagy: LC3-associated phagocytosis and endocytosis
Oct 26, 2022 · Autophagy, or more specifically mitophagy, could prevent inflammasome activation by removing damage mitochondria leading to reduced release of mitochondrial-derived …
Visualizing bulk autophagy in vivo by tagging endogenous LC3B
Feb 14, 2025 · We found that tfLC3-KI mice exhibit optimal expression of mRFP-eGFP-LC3B, allowing for convenient measurement of autophagic structures and flux at single-cell …
The autophagy component LC3 regulates lymphocyte adhesion …
Feb 4, 2025 · Direct interaction of LC3b with RAPL inhibits LC3b phosphorylation at T50 promoted by Rap1 activation via outside-in signaling, leading to FYCO1- and kinesin …
Role of the mammalian ATG8/LC3 family in autophagy: …
Autophagy is tightly regulated by proteins encoded by autophagy-related (atg) genes. Among these proteins, ATG8/LC3 is essential for autophagosome biogenesis/maturation and it also …
使用LC3B和p62来追踪自噬过程 - 赛默飞世尔科技公司
Premo™ Autophagy Sensor Tandem LC3B可用来区分酸性和中性LC3B阳性囊泡，从而可深入研究活细胞中的自噬作用随时间的变化。 细胞自噬作用首先是将胞质内含物（包括蛋白质和细 …